Tuesday, January 7, 2020

Insulin-producing Cells Derived from Stem Cells A...

Insulin-producing cells derived from stem cells: A potential treatment for diabetes Insulin was discovered over 75 years ago, however the complications of diabetes still produce devastating results (Bonner-Weir et al., 2006). Such complications are retinopathy, nephropathy and neuropathy which link between high blood glucose levels are now established beyond doubt (Bonner-Weir et al., 2006). Thus, ÃŽ ²-cell replacement therapy in the form of transplantation would be a great path to prevent the complications. â€Å"Î’-cell is defined as a cell with the phenotype of a mature insulin-producing cell found in pancreatic islets†(Bonner-Weir et al., 2006, p.411). Nevertheless, the supply of insulin-producing cells is insufficient thus limits the extension†¦show more content†¦Wang et al. (2012) stated that, one of the abundant source of adult stem cells is bone marrow. According to Weir et al. (2006), there is high possibility in circulating bone marrow cells could serve as precursors for a wide variety of cells scattered throughout the body. Cells other than true hematopoietic stem cells derived from bone marrow can serve as circulating stem or precursor cells. It has recently been shown that impressive repopulation of destroyed liver tissue can be generated from bone marrow cells. In addition, rather than a precursor, bone marrow cells could contribute to new ÃŽ ²Ã¢â‚¬â€œcell formation as a facilitator Bonner-Weir et al., 2006, p.411). Moreover, current study suggests that bone marrow contains pluripotent cells that are capable of being reprogrammed in order to differentiate into insulin-producing cells (Wang et al., 2012). Next, liver also works as a source of insulin-producing cells. Liver cells not only secreted insulin in a regulated manner but also reversed diabetes when transplanted into immunodifficient diabetic mice (Bonner-Weir et al., 2006, p.416). Pandey (2010) stated that, the liver appear to arise from the same cell population located within the embryonic endoderm during embryogenesis. Assumption has been done where the epithelial cell populations within the liver might share common stem cell populations (Pandey, 2010). Thus, another source for ÃŽ ²-cells would be liver stem cells. â€Å"Upon transplantation into diabetic mice, theseShow MoreRelatedStem Cell Research913 Words   |  4 PagesStem cells have long been used in many research studies as they have shown the ability to differentiate into different cell types, regenerate, and play a role in immune regulation. Studies with bone derived stem cells that I came across where focused on assessing the safety, limitations, and therapeuti c effects of bone derived stem cells in patients with varying diseases. Out of the many studies being conducted with stem cell transplantation and disease, the studies being investigating the potentialRead MoreThe Types Of Stem Cells1665 Words   |  7 PagesStem cells are a special type of cell that has the potential to differentiate into many different cell types. They work with in the body as an internal repair system. When they are not being used as a repair mechanism, the stem cells have the capability of long-term renewal. Because they are unspecialized cells, stem cells can be induced to become tissue or organ specific, thus giving them unique regenerative abilities that have the potential to treat diseases such as diabetes and Alzheimer’s. Read MoreThe Medical Promise Of Embryonic Stem Cells1626 Words   |  7 PagesEmbryonic Stem Cells Why should people suffer from diabetes, Alzheimer’s, sickle cell anemia, leukemia, and plenty of other degenerative diseases while the cure lies in our hands? After James Thompson, a developmental biologist, reported that he had derived the first human embryonic stem cell line (Thomson), the potential of curing degenerative diseases was revealed. Ph.D. holder and deputy director of FDA’s office of Cellular, Tissue and Gene Therapies, Stephanie Simek, explains that stem cells are unspecializedRead MoreDiabetes Is An All Inclusive Sugar Problem1550 Words   |  7 Pagesdiabetic or diabetes, most people not associated with the medical field think of only one type or that diabetes is an all inclusive sugar problem. The reality of diabetes mellitus is both complicated and simple at the same time. There are two types of the disease that will usually cause either low blood sugar or high blood sugar: type 1 (juvenile-onset), and type 2 (adult-onset). The root issue with both is actually an insulin production problem. Type 1 is called insulin-dependent diabetes a nd it’sRead MoreThe Idea of Using Stem Cell Therapy for Medical Treatments1788 Words   |  7 Pagesidea of using stem cell therapy for medical treatments is relatively new. A great deal of research and investment has gone into developing stem cells into viable medical treatments by making them more accessible and safe to use. Stem cell therapy is showing great promise to treat before untreatable diseases like type one diabetes. The idea of using stem cell therapy for medical treatments is relatively new. A great deal of research and investment has gone into developing stem cells into viableRead MoreResearch On Cell Therapy And Diabetes1985 Words   |  8 PagesCell Therapy and Diabetes The focus of this paper is to critique research that uses cell therapy to manage diabetes or to possibly reverse the main cause of the disease. The discussed research, proposes that there are studies that strongly support cell therapy as the cure for diabetes is achievable. Although some of the research might not give precise definition for a possible cure, I plan to critique the given articles and give an opinion regarding the possibilities of the existence of a cure forRead MoreThe Benefits Of Human Cloning : Pros And Cons1254 Words   |  6 Pagesregenerative medicine and assists those with physical disabilities by producing clones of themselves. Why clone themselves if they have a disability? Scientists can use cells from the embryo to customize the regeneration of the new organ, tissue, or body part. As far as cloning an organ goes, this benefits the millions of people who acquired a disease with no cure. For example, diseases such as Alzheimer’s, Parkinson’s and Diabetes, cloning has the ability to grow the organ or repair damaged tissueRead MoreIs Embryonic Stem Cell Research Ethical?951 Words   |  4 PagesIs Embryonic Stem Cell Research Ethical? The introduction and expansion of embryonic stem cell research initiated a highly debated ethical topic. Can our society agree to disagree? What are embryonic stem cells? What are stem cells? Is all stem cell research considered abortion? Debates surrounding embryonic stem cell research is further complicated by social standards and needs, religious beliefs, and personal morals. In November of 1998, a group of researchers announced that theyRead MoreStem Cell Research : Stem Cells1416 Words   |  6 PagesDana Moua English IV 25 April 2016 Stem Cell Research What are stem cells? Stem cells are undifferentiated cells that are found in multicellular organisms. The reason for scientist’s interest in stem cells is because of the possible applications of using them. These stem cells can be used to regrow organs/tissues. By using stem cells, scientists may be able to find cures for different cancers, certain genetic diseases, and different physical trauma damages. They can be used to treat a varietyRead MoreStem Cell Research has the Potential to Alleviate Much Suffering1425 Words   |  6 Pagesthe words of former First Lady Nancy Reagan: â€Å"Embryonic stem cell research has the potential to alleviate so much suffering. Surely, by working together we can harness its life-giving potential.† Stem cell research shows so much promise to help people by treating diseases and other problems through therapy. While it seems as though the clear answer is that we should study stem cells as soon as possible, this is sadly not the case. Stem cell research is an ongoing controversy within politics and the

No comments:

Post a Comment

Note: Only a member of this blog may post a comment.